Figure 5
Differential-expression of genes associated with H3K27Ac peaks. (A) Illustrative example quantifying the association of differentially expressed genes upon CS exposure with proximal H3K27Ac peaks identified as common to smoke- and air-exposed cells. The left panel shows the value of the t-statistics across all genes (color bar) and the genes that are annotated with a proximal common peak (ticks). The right panel shows box plots (median and inter-quartile range) of the t-statistic values for genes that have a proximal common peak (indicated by ticks in the left panel) and all other genes. The significance in the difference of these distributions is indicated. (B) The statistical association of the genes containing proximal H3K27Ac peaks with the differential-expression levels of genes in smoke compared to air exposed samples.
