Figure 2
From: Predictability and persistence of prebiotic dietary supplementation in a healthy human cohort
Inulin and pectin result in the enrichment of specific strains and specific enzymes in the metagenome across participants; in contrast, the same nutrient spike-in can also result in participant-specific responses. (a) Bacteroides uniformis blooms in response to inulin supplementation across all participants. The top plot shows mean and standard deviations of relative abundances across participants, and the bottom shows individual participant timeseries, normalized to relative abundance on day 3 for comparison purposes. (b) Same visualization for Bacteroides cellulosilyticus. (c) Average within-participant SNP heterozygosity in AMPHORA genes of B. uniformis. (d) Average between-participant SNP heterozygosity in AMPHORA genes of B. uniformis. (e) Relative abundance of pectinase enzymes in the metagenome. Statistical significance of the difference in abundance of pectinases on day 6 in the pectin arm was computed by a Wilcoxon Rank-Sum test compared to the abundance of pectinases on day 6 in the other arms (p < 10−5).
