Figure 1

AAV8 plasmid bearing the GNMT gene and GNMT protein expression in the liver tissues. (a) Representative diagram of AAV8 injection in Gnmt−/− (KO) mice. (b) The schematic construct of pAAV8-GNMT. (c) GNMT expression of 293T cells transfected with pAAV8-GNMT was measured by western blotting. The original picture of western blotting was provided in Fig. S1. (d) Staining for GNMT was performed on liver sections of WT, KO, KO-AAV8-eGFP and KO-AAV8-GNMT mice by immunohistochemical assessment.