Figure 1
From: Unfavourable gender effect of high body mass index on brain metabolism and connectivity
Brain hypometabolism AD patterns. (a) SPM-group analysis showing the typical AD brain hypometabolism pattern in the whole AD group. The analysis result is showed at p < 0.05 FWE corrected for multiple comparisons. (b) SPM-group analysis showing the typical AD brain hypometabolism pattern across low BMI vs. high BMI subgroups, separately for males and females (p < 0.05 FWE corrected for multiple comparison, k:100 voxels). (c) Results of the two-sample t-test comparisons between low BMI vs. high BMI gender subgroups. Significantly lower hypometabolism is present in precuneus/posterior cingulate cortex and parieto-temporal regions in females with high BMI as compared to females with low BMI (voxel-level p < 0.05 FDR corrected for multiple comparison, k = 100 voxels; cluster-level p < 0.05 FWE-corrected). No significant difference is revealed when comparing males with low vs. high BMI. The left side of the brain is shown on the left in the figure. Results are displayed on a 3D brain template using Brainnet toolbox48.
