Figure 5
From: MicroRNA miR-509 Regulates ERK1/2, the Vimentin Network, and Focal Adhesions by Targeting Plk1
miR-509 negatively regulates smooth muscle cell migration through Plk1. (A) Migratory paths of individual cells treated with miR-Ctrl or miR-509, or rescue cells. Treatment with miR-509 reduces accumulated distance (B), Euclidean distance (C), speed (D) and directionality (E), which is restored in rescue cells. Data are mean values of 31 miR-Ctrl treated cells, 36 miR-509 treated cells and 23 rescue cells. Error bars indicate SD (*p < 0.05). One-way ANOVA was used for statistical analysis of B–E.
