Figure 5
From: KRASG12D and TP53R167H Cooperate to Induce Pancreatic Ductal Adenocarcinoma in Sus scrofa Pigs
Schema Summarizing the LSL-KRASG12D-TP53R167H porcine model of PDAC. By isolating pancreatic duct cells from LSL-KRASG12D-TP53R167H pigs and transducing with Adeno-Cre in vitro, cells self-immortalized and were able to established tumors in xenograft experiments using immunocompromised mice. Similarly, when Adeno-Cre was administered to the main pancreatic duct in vivo, LSL-KRASG12D-TP53R167H pigs developed extensive PDAC along the injection site.
