Table 1 Pharmacokinetic parameters of Tα1-Fc after a single intravenous injection (n = 3).

From: Thymosin Alpha1-Fc Modulates the Immune System and Down-regulates the Progression of Melanoma and Breast Cancer with a Prolonged Half-life

Two-compartment model

Tα1

Tα1-Fc

Cmaxa (ng/L)

74.347

118.896

Tmaxb (h)

1.5

13

t1/2zc (h)

1.933

24.576

AUC(0-∞)d (ng/L*h)

191.934

8146.158

Vde (L/kg)

0.025

0.011

Ff (%)

98.69

90.70

  1. aMaximum concentration; btime to maximum concentration; celimination half-life;
  2. darea under concentration-time curve; eapparent volume of distribution; fabsolute bioavailability.
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