Figure 5 | Scientific Reports

Figure 5

From: Mapping discontinuous epitopes for MRK-16, UIC2 and 4E3 antibodies to extracellular loops 1 and 4 of human P-glycoprotein

Figure 5

Role of K323G substitution in ECL3 of the mouse P-gp-ECL13&4-h19 chimera. (A) Schematic of the 2-D structure of mouse-ECL13&4-h19 chimera. The ECLs 1, 3 and 4 are enlarged in insets. (Other details are the same as given in the legend to Fig. 4). (B) Histograms from a representative experiment depict UIC2, MRK-16 and 4E3 antibody staining of the mouse-ECL134-h19 chimera.

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