Figure 7
Docking of UIC2 and MRK16 Fab to mouse P-gp-ECL1&4-h18 chimera. The Fab of UIC2 and MRK-16 were docked separately on the homology model of mouse-ECL1&4-h18 P-gp mutant. The extracellular portions of P-gp, which interact with the MRK-16 (A) or UIC2 (B) Fabs are magnified. The Fab regions are shown as electrostatic surface potentials. The N-terminal half of the P-gp molecule is in green and the C-terminal is in cyan. The ECLs, transmembrane regions, and interacting residues are labeled. The substituted human residues interacting with Fab regions are shown as sticks. These figures were prepared using Chimera version 7.
