Figure 3

Immunohistochemical validation of tenascin-C and carbonic anhydrase 3. Shown are MALDI IMS spectra displaying the identified average m/z species of (a) tenascin-C (TnC) and (b) carbonic anhydrase 3 (Ca3) within the tam and tm region of MSC-TX and control muscles, respectively. Immunohistochemical staining revealed a stronger expression of TnC (above right subplot) in tam region of MSC-TX muscle, whereas the expression of Ca3 is elevated in the tam region of control muscles.