Figure 5 | Scientific Reports

Figure 5

From: Histo-blood group antigen-binding specificities of human rotaviruses are associated with gastroenteritis but not with in vitro infection

Figure 5

Binding of HAL1166 and SA11 VP8* to HBGAs measured by saliva-based binding assay. VP8* proteins from two cell culture-adapted strains (HAL1166 (P[14]) and SA11 (P[2])) were tested for binding to a panel of previously well-defined A, B, O, secretor and Lewis types saliva samples (SE = Secretor (FUT2 + ); se = non-secretor (FUT2−); Le+  = Lewis positive (FUT3+); le− = Lewis negative (FUT3−); A = Blood group A). HAL1166 VP8* (a) binds to mucins of SE/A phenotypes only (SE non A n = 28, SE A n = 16 and se n = 15) whereas SA11 VP8* (b) does not bind to human salivary mucins (SE/Le+ n = 32, SE/le− n = 12, se/Le+ n = 11 and se/le− n = 4). Mann-Whitney test was used to compare groups (***p < 0.001).

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