Figure 1

The conceptual schematics of this study. The GSK-3 inhibitor was intraperitoneally (i.p.) injected and microbubbles were intravenously (i.v.) injected. During the sonication induced by a focused ultrasound transducer, GSK-3 inhibitor penetrated the blood-brain barrier to block/reduce the Aβ peptide synthesis and overexpression.