Figure 9 | Scientific Reports

Figure 9

From: Isoform-specific hyperactivation of calpain-2 occurs presymptomatically at the synapse in Alzheimer’s disease mice and correlates with memory deficits in human subjects

Figure 9

Protein levels of calpain-2 are higher in frontal neocortical tissue samples of post-mortem brains of AD patients in a synaptosome-specific manner. (A) Immunoreactive levels of calpain-2 were increased in synaptosomes isolated from post-mortem brains of AD patients when compared to subjects with MCI as well as subjects with NCI. (B) Global calpain-2 protein levels were unaltered in post-mortem AD brains. Values are mean ± SD (n = 12 subjects) and * and # denote significant difference from NCI and MCI groups respectively (p < 0.05; ANOVA followed by post hoc tests with Newman-Keuls correction). See full representative blots in Supplementary data (Supplementary Figs 14,15).

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