Table 1 Network Characteristics of PCOS Genes.

Dataset	Class	Size	Degree	K-Core	Betweenness	1st PCOS Ratio	2nd PCOS Ratio
Total	PCOS	306	41.81	16.78	34463	0.11	0.04
	Non-PCOS	16676	22.48	11.66	17278	0.04	0.03
	P value		4.2E-13	1.7E-10	1.4E-17	3.0E-48	6.0E-20
PCOSDB	PCOS	185	50.54	18.78	40177	0.10	0.03
	Non-PCOS	16676	22.48	11.66	17278	0.02	0.02
	P value		1.5E-12	5.2E-10	2.0E-12	2.0E-36	1.3E-09
PCOSKB	PCOS	226	38.60	15.43	33614	0.09	0.04
	Non-PCOS	16676	22.48	11.66	17278	0.03	0.02
	P value		2.6E-07	9.1E-07	5.3E-12	1.5E-32	1.1E-20

“Total” indicates all the PCOS genes covered by either PCOSDB or PCOSKB. “Non-PCOS” indicates the remaining genes. The degree of a gene is defined as the number of its direct interaction genes. A K-core of a network can be obtained by recursively deleting genes with a degree lower than K, until the remaining genes in subnetwork have a degree higher than K. Betweenness counts the number of times that a gene is on the shortest path between two other genes. 1st PCOS ratio is defined as the ratio of the number of PCOS genes that it direct interacts to its degree. 2nd PCOS ratio is defined as the ratio of the number of PCOS genes that belong to 2nd interaction genes to its number of 2nd interaction genes. The P values were calculated by KS test. PCOS represents polycystic ovary syndrome.

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