Figure 5 | Scientific Reports

Figure 5

From: Germinated soy germ with increased soyasaponin Ab improves BMP-2-induced bone formation and protects against in vivo bone loss in osteoporosis

Figure 5

GSGE prevents OVX-induced bone loss in vivo. (a) Longitudinal and transverse µ-CT images of Con and OVX at 0.1 mg, 1 mg, and 5 mg from left to right, and (b) bone mineral density, percent bone volume ratio, trabecular bone number, trabecular bone volume, and trabecular bone thickness of femur measurements by 3D images analyzer. ##p < 0.01 (versus Con group); **p < 0.01 (versus OVX group). (c) Mice were euthanized 12 weeks after GSGE treatment, and femurs were dissected, fixed, decalcified, and sectioned. Sections were stained with H&E. Stained bone sections were photographed under a light microscope (scale bar, 200 μm). (d) Femur trabecular volume/tissue volume and femur weight/body weight were analyzed using the Visus image analysis program. ##p < 0.01 (versus Con group); **p < 0.01 (versus OVX group). (e) Blood was collected from abdominal veins through the laparotomy incision. BALP concentration was estimated using an ELISA kit. ##p < 0.01 (versus Con group); **p < 0.01 (versus OVX group).

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