Figure 5
Differential expression analysis in melanoma cell lines with different TFAM expression, joining transcriptomic data generated by our group and by Pawlikowski et al.24. (A) Volcano plot showing the highly different expressed genes up (red dots) and down-regulated (green dots) in TFAM down cell lines; (B) Heatmap with the gene expression pattern of the HIF-α main targets, that were categorazed according with their role in tumorigenesis. The analysis revealed two distinct genes clusters, highlighted in dotted red lines. FDR: False discovery rate.
