Figure 6 | Scientific Reports

Figure 6

From: Mitochondrial transcription factor A (TFAM) shapes metabolic and invasion gene signatures in melanoma

Figure 6

Differential expression analysis of metabolic enzymes between TFAM-Up and TFAM-Down in metastatic melanoma. (A) Gene ontology pathways enriched with the differentially expressed enzymes. Each circle represents gene pathways and correlated pathways are linked. The sizes of the circles are proportional to the enrichment analysis p-values; (B) Heatmap showing the top 54 genes differently expressed between TFAM up and down metastatic melanoma samples. Color bar at the bottom indicates the presence of mutations in BRAF, RAS and NF1 genes. AMP: Gene Amplification; WT: Wild-type; MUT: Mutated.

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