Figure 5 | Scientific Reports

Figure 5

From: ALS-causing mutations in profilin-1 alter its conformational dynamics: A computational approach to explain propensity for aggregation

Figure 5

Protein fluctuations during 200 nanosecond simulations of isolated PFN1WT, PFN1G118V, and PFN1T109M. (A,B) Backbone root-mean-square deviation (RMSD) and residue-based Cα root-mean-square fluctuation (RMSF) for PFN1WT, (C,D) PFN1T109M, and (E,F) PFN1G118V. In each case, 3 independent 200-ns trajectories were performed and analyzed as shown in each panel. (G) The three trajectories of each system were then combined to generate the residue-based Cα RMSF shown for PFN1WT (magenta), PFN1T109M (green), and PFN1G118V (blue).

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