Figure 4
Brain lipid profiles show that OEA significantly decreases the VLCFA in the brains of GWI mice. Mean ± SEM expressed as percent control of mice on normal chow (n = 4/5 per group). (A) Levels of VLCFA were increased in the brains of GWI mice compared to control mice. OEA treated GWI mice had similar levels as in control mice. However, control mice treated with OEA had significantly higher levels of VLCFA compared to control mice that received normal diet. (B) Quantification of lipid peroxidation product TBARS showed that levels were significantly elevated in GWI compared to control mice on normal chow but were lower in OEA treated GWI mice compared to all other groups. (C) Compared to controls, GWI mice had higher levels of several major omega-6 and omega-3 FA (FA20:4, FA22:4. FA22:5, FA24:5 and FA24:6). Treatment with OEA decreased the levels of these FA in GWI mice. *p ≤ 0.05.
