Figure 5
OEA treatment reduced elevated astroglia activation in GWI mice. Confocal microscopy images showing staining of astroglia with GFAP (n = 4 per group, 4 serial sections for each animal). Scale bar 50 μm. (A) Images show 20x GFAP staining (red) and DAPI (blue) in the cortex and the DG of mice from all 4 treatment groups. (B) Images show 100x magnification of GFAP stained astroglia in the cortex of each study treatment group. (C) Quantification of GFAP staining from 20x images. There are significant increases in GFAP staining for both the cortex and the DG within the hippocampus of GWI compared to control mice. GWI mice treated with OEA had similar levels as control mice on normal chow. Control mice treated with OEA had higher levels than control mice on the normal diet. *p ≤ 0.05.
