Figure 6
From: Graves’ orbitopathy occurs sex-independently in an autoimmune hyperthyroid mouse model
Comparison of male versus female GO mouse model. To compare the total outcome of male versus female autoimmune hyperthyroidism or associated orbitopathy, the characteristic parameters were normalized by the Z-Score method. (A) Z-Score of autoimmune hyperthyroidism includes values of TSAbs (Fig. 1), T4 and thyroid area (Fig. 2). (ß-Gal males n = 10, females n = 15; hTSHR males n = 14, females n = 14) (B) Z-Score of orbitopathy evaluated by MRI includes parameter inflammatory infiltration, fat extension and GaG deposition (Fig. 4). (ß-Gal males n = 4, females n = 6; hTSHR males n = 6, females n = 5) (C) Z-Score of orbitopathy characterized by the histological parameter of, abundance of macropahes, T cells, muscle fiber hypertrophy, BAT extension and collagen deposition (Fig. 5). (ß-Gal males n = 8, females n = 15; hTSHR males n = 14, females n = 14). Statistical significance is given with **p ≤ 0.01, *p ≤ 0.05, ns non-significant.
