Figure 1 | Scientific Reports

Figure 1

From: Novel insight into the reaction of nitro, nitroso and hydroxylamino benzothiazinones and of benzoxacinones with Mycobacterium tuberculosis DprE1

Figure 1

Mechanism of inhibition of DprE1 by BTZs. (i) noncovalent recognition of nitro(NO2)-BTZs by DprE1; (ii) reduction of nitro-BTZs to nitroso(NO)-BTZs by DprE1; (iii) release of nitroso-BTZs; (iv) covalent binding of nitroso-BTZs to Cys387; (v) cleavage of the bond between BTZs and DprE1; (vi) noncovalent recognition of hydroxylamino(NHOH)-BTZs by DprE1; (vii) oxidation of the hydroxylamino-BTZs to nitroso-BTZs by DprE1.

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