Figure 2 | Scientific Reports

Figure 2

From: Polymorphisms of SLCO1B1 rs4149056 and SLC22A1 rs2282143 are associated with responsiveness to acitretin in psoriasis patients

Figure 2

Cellular levels of acitretin with different SLCO1B1 rs4149056 alleles. Legend: (A) Uptake of acitretin was significantly higher in HEK293-SLCO1B1 cells than in HEK293-MOCK cells. (B) Uptake mediated by SLCO1B1 521 C allele was less than that in the wild-type 521 T cells. (C,D) Uptake of acitretin mediated by SLCO1B1 was inhibited by rifampicin. SLCO1B1 521 T is the wild-type allele, and 521 C is the variant.

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