Figure 7

Effects of antipsychotics on impaired rotarod performance in Reln^rl-Orl/+ mice. (a) Experimental protocol for the pharmacological study with haloperidol or clozapine. (b and c) Effects of haloperidol on impaired performance in the training phase (b) and test phase (c). Data represent the mean ± SEM (n = 25 for vehicle-treated WT mice; n = 24 for vehicle-treated Reln^rl-Orl/+ mice; n = 22 for haloperidol-treated WT mice; n = 22 for haloperidol-treated Reln^rl-Orl/+ mice). *p < 0.05 and **p < 0.01, significantly different from vehicle-treated WT mice. ^#p < 0.05, significantly different from vehicle-treated Reln^rl-Orl/+ mice. (d and e) Effects of clozapine on impaired performance in the training phase (d) and test phase (e). Data represent the mean ± SEM (n = 21 for vehicle-treated WT mice; n = 20 for vehicle-treated Reln^rl-Orl/+ mice; n = 22 for clozapine-treated WT mice; n = 22 for clozapine-treated Reln^rl-Orl/+ mice). *p < 0.05 and **p < 0.01, significantly different from vehicle-treated WT mice. ^#p < 0.05 and ^##p < 0.01, significantly different from vehicle-treated Reln^rl-Orl/+ mice.