Table 1 Comparison of behavioral changes in Reln mutant mice.

From: Genetic and animal model analyses reveal the pathogenic role of a novel deletion of RELN in schizophrenia

Mutant mice strains (Background)

Sobue et al.49

(Present study)

Lalonde et al.30

Tueting et al.21

Salinger et al.22

Qiu et al.4

Sakai et al.19

Orleans hetero (BALB/C)

Orleans homo (BALB/C)

Jackson hetero (B6C3Fe)

Jackson hetero (B6C3Fe)

Jackson hetero (B6C3Fe)

ΔC-KI (C57BL/6)

Age

10–15 weeks ♂♀

12 weeks ♂

9 weeks ♂

10 weeks ♂

6 weeks ♂

11 weeks ♂

Gait width

n/a

n/a

n/a

=

n/a

n/a

Nose poke

n/a

n/a

n/a

=

n/a

n/a

Stationary beams

n/a

↓

n/a

n/a

n/a

n/a

Coat-hanger test

n/a

↓

n/a

n/a

n/a

n/a

Visual cliff

n/a

n/a

n/a

=

n/a

n/a

Acoustic responsiveness

n/a

n/a

n/a

↑(Intensity response)

n/a

n/a

Olfactory guidance

n/a

n/a

n/a

=

n/a

n/a

Grip strength

n/a

n/a

n/a

n/a

n/a

=

Wire hang latency

n/a

n/a

n/a

n/a

n/a

↓

Locomotor activity

=

↑

=

n/a

n/a

n/a

Open field

↑

↑

n/a

=

=

↑

Light dark test

n/a

n/a

n/a

=

=

=

Elevated plus maze

=

↓

↓

n/a

=

↑

Tail suspension test

n/a

n/a

n/a

n/a

n/a

=

Porsolt forced swim test

n/a

n/a

n/a

n/a

n/a

=

Y-maze

=

n/a

n/a

n/a

n/a

=

Barnes maze test

n/a

n/a

n/a

n/a

n/a

=

T-maze

n/a

=

n/a

n/a

n/a

↓(Working memory)

Novel object recognition

=

n/a

n/a

↓

n/a

n/a

Social interaction test

↓

n/a

n/a

=

n/a

↓

Rotarod test

↓

↓

n/a

n/a

=

↑

Fear conditioning test

n/a

n/a

n/a

=

↓(Context)

=

Water maze test

n/a

↓

n/a

n/a

=

n/a

Hot plate test

n/a

n/a

n/a

n/a

n/a

=

Prepulse inhibition

↑(Acoustic response)

n/a

↓(80 dB 55–63 days)

=

↓(82 dB)

=

MK801-induced hyperlocomotion

=

n/a

n/a

n/a

n/a

n/a

METH-induced hyperlocomotion

↓

n/a

n/a

n/a

n/a

n/a

  1. ↑Higher than wild type; ↓lower than wild type; =no difference; n/a: not applicable.
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