Table 3 Summary of the rate of sustained plateau of Ca2+ signal (cell death process) induced by glutamate in different conditions.

From: Dual action of L-Lactate on the activity of NR2B-containing NMDA receptors: from potentiation to neuroprotection

Glutamate/Glycine (1 mM/100 μM; 2 min)

% Ca2+ sustained plateau (Cell death process)

One-Way Anova

Control

(ncult = 7; ncells = 263)

51.4 ± 6.7

 

Ifenprodil (2 μM)

(ncult = 6; ncells = 260)

9.7 ± 3.4

<0.005

L-Lactate (2 mM)

(ncult = 6; ncells = 338)

42.6 ± 7.8

n.s

L-Lactate (5 mM)

(ncult = 6; ncells = 302)

28.7 ± 4.9

<0.05

L-Lactate (10 mM)

(ncult = 8; ncells = 282)

22.7 ± 3.7

<0.005

Pyruvate (10 mM)

(ncult = 6; ncells = 264)

9.0 ± 3.7

<0.005

D-Lactate (10 mM)

(ncult = 6; ncells = 246)

38.5 ± 7.4

n.s

L-Lactate (10 mM) + carbenoxolone

(10 μM) (ncult = 5; ncells = 164)

42.8 ± 3.5

n.s

L-Lactate (10 mM) + glibenclamide

(200 μM) (ncult = 4; ncells = 141)

36.0 ± 4.0

n.s

DTT (1 mM)

(ncult = 6; ncells = 154)

54.0 ± 7.5

n.s

  1. Values are means ± SEM. Statistics data correspond to a Dunnett’s post hoc test following a one-way ANOVA (n.s: non significant, p > 0.05).
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