Table 2 Time course of activation (τON) and deactivation (τOFF) of calcium currents before and after acute application of HDAC inhibitors.

From: Class II histone deacetylases require P/Q-type Ca2+ channels and CaMKII to maintain gamma oscillations in the pedunculopontine nucleus

 

SB + TTX + TEA-Cl

+TSA (1 μM)

SB + TTX + TEA-Cl

+MC1568 (1 μM)

SB + TTX + TEA-Cl + KN93 (1 μM)

+TSA (1 μM)

τON (ms)

3.2 ± 0.9 (n = 7)

8.7 ± 2.8 (n = 7; p > 0.05)

3.1 ± 1.4 (n = 8)

8.7 ± 3.4 (n = 8; p > 0.05)

2.8 ± 0.8 (n = 7)

3.6 ± 1.0 (n = 7; p > 0.05)

τOFF (ms)

2.2 ± 0.6 (n = 7)

5.1 ± 1.3 (n = 7; p > 0.05)

2.6 ± 0.9 (n = 8)

6.2 ± 1.7 (n = 8; p > 0.05)

1.1 ± 0.3 (n = 7)

1.7 ± 0.3 (n = 7; p > 0.05)

  1. Paired Student’s t-test comparisons showed no significant differences:
  2. Acute TSA (1 μM): τON; t = 2.3, df = 6, p = 0.06, τOFF; t = 2.4, df = 6, p = 0.055.
  3. Acute MC1568 (1 μM): τON; t = 2.2, df = 7, p = 0.06, τOFF; t = 2.3, df = 7, p = 0.06.
  4. Acute KN93 (1 μM) + TSA (1 μM): τON; t = 2.2, df = 6, p = 0.07, τOFF; t = 1.3, df = 6, p = 0.23.
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