Figure 5
E-cadherin deletion promotes upregulated YAP signaling in the postnatal pancreas. (A–D) Immunofluorescence analysis of Yap (red), Epcam (green), and DAPI (blue) in the control (A,C) or Cdh1ΔPan/ΔPan (B,D) pancreas at P0 and P4. Dashed white bounding boxes indicate dimensions of the projected area for each individual panel to the right (A’–D”). White scale bars = 100 μm. White asterisks indicate dilated/cystic exocrine structures. (E) qRT-PCR analysis of the YAP transcription effectors Ctgf, Amotl2, Ankrd1 and Cyr61. Histograms represent mean ± SEM of at least three independent determinations. For 2-tailed t-tests, *p < 0.05, **p < 0.01, ***p < 0.001 compared to control.
