Figure 5

Memory formed under MK-801 is able to be retrieved by inducing delta oscillations in neocortex. (a) Experimental design for testing memory transfer between the MK-801-induced state and state induced by 3 Hz stimulation. Thy1-ChR2 mice were trained (2 s, 0.6 mA, 3 foot shocks) under MK-801 and memory test was performed under different conditions. (b) Mice showed increased freezing during the 3-min-light-on epochs when tested in the conditioning context (n = 8 mice, one-way ANOVA followed by Tukey’s test). (c) Freezing behavior during the light-on epochs was as robust as that tested under MK-801 (n = 8 mice, paired t test). (d) Mice did not show light-associated increase of freezing behavior when tested in a novel context (n8 mice, paired t test). ns: P > 0.05, *P < 0.05, **P < 0.01. Data presented as mean ± SEM. (e) Schema illustrates the MB as a key regulator of brain state for state-dependent memory through regulating brain oscillations.