Figure 3

Overview of important variable positions on both the HN and F protein, as described in the literature. (A) The F protein important functional regions with glycosylation sites (yellow), fusion promotion sites (orange), cleavage site (pink), neurovirulence (dark blue) and known B-cell epitope regions (green) mapped on the pre-fusion structure. Zoom is on the variation at position 97 (cyan blue) near the cleavage site (pink). (B) The HN protein with glycosylation sites (yellow), fusion promotion sites (orange), receptor-binding regions (pink), neuraminidase activity regions (cyan blue), Ca²⁺-binding sites (red), neurovirulence regions (dark blue), known T-cell epitope (purple) and known B-cell epitope regions (green) mapped on the structure. Zoom is on the variations at positions 354, 356 and 442 (brown positions).