Figure 6
From: Potent PDZ-Domain PICK1 Inhibitors that Modulate Amyloid Beta-Mediated Synaptic Dysfunction
PICK1 inhibitor blocks long term depression. Long term depression (LTD) responses from vehicle-treated slices (●) and after treatment with PICK1 inhibitor (compound 1r, 4 µM) (
) internally before and after low frequency stimulation (LFS). Each point is the Mean ± SEM of 6 slices from 6 animals treated with control, and 9 slices from 7 animals in compound 1r. Inset shows EPSP traces of control slice before (1) and after LFS (2) revealing significant inhibition of LTD in the presence of compound 1r (1 + 2 overlay). EPSC, excitatory post synaptic current.
