Figure 6
From: Impaired microcirculation after subarachnoid hemorrhage in an in vivo animal model
Effects of cerebrospinal fluid from rats (rCSF) after subarachnoid hemorrhage (SAH) on microcirculation of naïve rats. CSF from rats 24 hours after SAH (rCSF) was applied on the brain surface of naïve rats. Vascular diameters, including primary arterioles (pa), secondary arterioles (sa), and terminal arterioles (ta), were measured using a capillary videoscope at different time points following rCSF superfusion. (A,B) Marked vasoconstriction was observed in all types of arteriole at 1 min after rCSF application. (C) At 120 min, vasoconstriction persisted in the sa and ta. (D,E) The vasoconstrictive effect was alleviated by normal saline irrigation; i.e., the diameters of the sa and ta returned to the pre-rCSF level within 1 min of normal saline irrigation and persisted if normal irrigation continued. (a: primary arteriole, v- vein, arrow: secondary arteriole, arrow head: terminal arteriole).
