Figure 8
From: Impaired microcirculation after subarachnoid hemorrhage in an in vivo animal model
Effects of cerebrospinal fluid from human subjects (hCSF) with subarachnoid hemorrhage (SAH) on microcirculation of normal rats. This figure demonstrates microcirculation changes following superfusion of hCSF from SAH patients. Superfusion of hCSF from the control group resulted in no microcirculation changes (A1,A2), while hCSF from SAH patients without DIND (B1,B2) typically caused mild microcirculation changes of secondary arterioles (sa, arrow) and terminal arterioles (ta, arrowhead). After superfusion with hCSF from patients with DIND, constriction of the sa (arrow) and ta (arrowhead) occurred rapidly within 5 min. Such vasoconstriction of the sa and ta progressed to total occlusion 2 hours later (C1,C2). Statistical analysis showed that the degrees of vasoconstriction of the sa and ta were higher in the SAH patients with DIND than in those without DIND (D,E). The degrees of constriction of the sa and ta were highly correlated (F). (a: primary arteriole, v- vein, arrows: secondary arterioles, arrowheads: terminal arterioles).
