Figure 1

Top. ALDHTt monomeric and tetrameric domain architecture in ribbon illustration. Monomer A consists of the catalytic domain (green), NAD(P)+ binding domain (blue), short linker loop (yellow), inter-domain linker (orange), oligomerisation domain (cyan) and the C-terminal tail (red). Bottom. Surface representation of the tetrameric assembly of ALDHTt showing intimate relationship between protomers. Coloring for monomer A’s domains is kept consistent to aid orientation. Monomers B, C and D are colored in purple, light brown, and pink respectively.