Figure 3
From: Predicting proteome dynamics using gene expression data
Variable half-life allows best fit of predicted (red) and experimentally measured (green) temporal protein concentration profiles (A,B). Previously reported half-lives9,14 (left) for Clb2 do not lead to good fit of predicted and measured protein concentration temporal profiles (right), especially for half-life reported in Belle et al.9. (C)Â Variable half-life (left), found through numerical simulations (Material and Methods) allows for best fit between dynamic Clb2 abundances predicted from mRNA time-course and measured protein abundance time-course from the same condition.
