Figure 3
From: A soy protein Lunasin can ameliorate amyloid-beta 42 mediated neurodegeneration in Drosophila eye
Lunasin (Lun) misexpression can restore Aβ42 mediated impairment of axonal targeting from retina to brain. Chaoptin (MAb24B10), a marker for the axonal targeting from retina to the optic lobes of the brain. (A) In wild-type eye imaginal discs, the retinal axons marked by MAb24B10 innervate the lamina and medulla of the brain. (B) Misexpression of GMR > Aβ42 in the developing eye imaginal discs result in impaired targeting of retinal axons to the brain. However, (C) misexpression of Lunasin (Lun) along with Aβ42 (GMR > Aβ42 + Lun) resulted in significant restoration of the axonal targeting to near wild-type. Monoclonal antibody 22C10 marks all axonal sheath of the photoreceptors in the developing eye. 22C10 expression in (D) Wild-type, (E) GMR > Aβ42 and (F) GMR > Aβ42 + Lun background. Note that impairment of 22C10 expression in GMR > Aβ42 background is restored significantly in GMR > Aβ42 + Lun background. Magnification of all eye discs is 20X.
