Figure 1 | Scientific Reports

Figure 1

From: The first crystal structure of a DNA-free nuclear receptor DNA binding domain sheds light on DNA-driven allostery in the glucocorticoid receptor

Figure 1

Crystal structure of the DNA-free GR DBD. (A) Dimerization via formation of a disulfide between adjacent C431 residues. (B) Overall structure of the free GR-DBD with important structural elements highlighted. (C) The orientation of helix H3 differs between the free DBD and the DNA-bound state. In the DNA-bound state H3 lies across the major groove and makes interactions with the DNA phosphate backbone. The conformation of H3 found in the free state is rotated by ~60 degrees so that the helix lines up perpendicular to the major groove.

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