Figure 5 | Scientific Reports

Figure 5

From: The first crystal structure of a DNA-free nuclear receptor DNA binding domain sheds light on DNA-driven allostery in the glucocorticoid receptor

Figure 5

Structural elements of GR DBD in the DNA-free state. (A). Hydrogen-bonds forming the antiparallel beta-sheet in the N-terminal Zn finger in the DNA-free GR DBD structure. (B) The short, distorted helix in the C-terminal Zn finger in DNA-bound (PDB ID: 3G99) and free GR DBD adopt the same conformation. (C) Conformation of the DNA reading helix. Shown is a structural alignment of a representative molecule of DNA-free GR DBD with DNA-bound GR-DBD (3G99). The DNA reading helix aligns well between the two proteins and the position of two residues that make direct contact with the DNA in 3G99 is unchanged in the DNA-free structure.

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