Table 1 Top 20 DEGs based on p-value from microarray expression analysis of DA neurons following perinatal nicotine exposure compared to saline control. Predicted miRNA targets are also included.

From: Investigating the genetic profile of dopaminergic neurons in the VTA in response to perinatal nicotine exposure using mRNA-miRNA analyses

Gene Symbol

Entrez ID

Log FC

adj p val

Description

miRNA target

Upregulated

Nepn

309775

1.635

0.00093

nephrocan

 

Spert

498572

3.824

0.00118

spermatid associated

 

Map2

25595

1.365

0.00124

microtubule-associated protein 2

 

Pced1b

315283

3.652

0.00138

PC-esterase domain containing 1B

 

LOC103691883

103691883

2.475

0.00153

uncharacterized LOC103691883

 

Sept11

305227

1.017

0.00166

septin 11

rno-miR-30b-5p, rno-miR-30d-5p

Ptp4a2

85237

1.114

0.00175

protein tyrosine phosphatase type IVA, member 2

rno-miR-290

S100a1

295214

1.243

0.00175

S100 calcium binding protein A1

 

LOC102547613

102547613

2.412

0.00175

uncharacterized LOC102547613

 

LOC103691014

103691014

1.545

0.00175

uncharacterized LOC103691014

 

Rnf126

314613

2.96

0.00186

ring finger protein 126

 

LOC103693092

103693092

2.542

0.00191

uncharacterized LOC103693092

 

Sepp1

29360

1.164

0.00194

selenoprotein P, plasma, 1

 

Lrrc25

498605

1.536

0.00208

leucine rich repeat containing 25

 

Nkain3

689576

1.466

0.00219

Na + /K + transporting ATPase interacting 3

 

Bcas1

246755

1.46

0.00240

breast carcinoma amplified sequence 1

rno-miR-214-3p

Bcl11a

305589

2.137

0.00242

B-cell CLL/lymphoma 11 A (zinc finger protein)

 

Bmx

367786

3.555

0.00242

BMX non-receptor tyrosine kinase

 

Gpm6b

192179

1.26

0.00245

glycoprotein m6b

 

LOC102553223

102553223

1.118

0.00245

uncharacterized LOC102553223

 

Downregulated

LOC103692792

103692792

−5.074

0.00014

inactive phospholipase C-like protein 2

 

Pfkp

60416

−2.062

0.00041

phosphofructokinase, platelet

 

Atp13a1

290673

−3.882

0.00041

ATPase type 13A1

rno-miR-335

LOC102546798

102546798

−2.342

0.00041

uncharacterized LOC102546798

 

LOC102557363

102557363

−2.301

0.00041

uncharacterized LOC102557363

 

Cldn11

84588

−1.783

0.00048

claudin 11

rno-miR-500-3p

Cstf2

683927

−2.386

0.00050

cleavage stimulation factor, 3′ pre-RNA subunit 2

 

LOC102546798

102546798

−1.664

0.00055

uncharacterized LOC102546798

 

Agpat4

170919

−1.539

0.00058

1-acylglycerol-3-phosphate O-acyltransferase 4

 

LOC100359748

100359748

−2.02

0.00058

zinc finger CCCH type, antiviral 1

 

Mfsd6

301388

−3.487

0.00070

major facilitator superfamily domain containing 6

rno-miR-30b/e-5p,

rno-miR-301a-3p,

rno-miR-130a-3p,

rno-miR-26a-5p,

rno-miR-101a/b-3p

LOC102554532

102554532

−2.769

0.00070

uncharacterized LOC102554532

 

LOC102555987

102555987

−2.624

0.00070

uncharacterized LOC102555987

 

Snrpn

81781

−2.153

0.00077

small nuclear ribonucleoprotein polypeptide N

 

LOC103693598

103693598

−3.972

0.00077

uncharacterized LOC103693598

 

Pgap3

688174

−3.218

0.00079

post-GPI attachment to proteins 3

 

LOC102557525

102557525

−3.072

0.00079

disks large homolog 5-like

 

Uchl1

29545

−1.425

0.00085

ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

 

Kcnt1

60444

−2.582

0.00093

potassium channel, sodium-activated subfamily T, member 1

rno-miR-324-5p

Slc7a8

84551

−3.219

0.00093

solute carrier family 7 (amino acid transporter light chain, L system), member 8

 
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