Figure 6
From: Anti-TNFR1 targeting in humanized mice ameliorates disease in a model of multiple sclerosis
T cell cytokine secretion is unchanged by anti-TNFR1 treatment. T cells were isolated from lymph nodes following the second injection of ATROSAB/control IgG on days 5 or 6 of acute EAE. Following isolation and purification, T cells were re-stimulated with either anti-CD3 or MOG35−55 and ELISAs performed for IFNγ (A), IL17A (B) and TNFα (C). However, no differences were seen between T cells from both treatment groups in the secretion of either cytokine. n = 6 per treatment. ATR, ATROSAB.
