Figure 8
From: Increased Phosphaturia Accelerates The Decline in Renal Function: A Search for Mechanisms
In HEK-293 cells, the addition of melatonin prevents oxidative stress induced by high levels of inorganic phosphate. Intracellular ROS were determined by using the probes (A) DHRH and (B) CMFDA after 24 hours of incubation in a medium containing normal P concentration (0.9 mM), high levels of phosphate (5 mM P) and high phosphate plus melatonin (10−5 M). ap < 0.001 vs normal phosphate; bp < 0.001 vs 5 mM phosphate.
