Table 4 Multiple regression analyses evaluating insulin-stimulated glucose disposal as dependent variable in four models of increasing complexity.

	Independent contributors	Standardized Coefficient β (95% CI)	P
Model 1 includes IgG2, gender, age, and BMI.	BMI	−0.353 (−0.278 to −0.145)	<0.0001
	Gender (male)	−0.199 (−2.319 to −0.649)	0.001
	IgG2	−0.141 (−0.622 to −0.071)	0.01
Model 2 includes IgG2, gender, age, BMI, smoking status, blood pressure, total and HDL cholesterol, triglycerides, fasting and 2 h post-load plasma glucose.	2 h post-load glucose	−0.240 (−0.052 to −0.020)	<0.0001
	BMI	−0.220 (−0.193 to −0.055)	<0.0001
	Age	0.136 (0.001 to 0.094)	0.03
	IgG2	−0.120 (−0.535 to −0.012)	0.02
Model 3 includes IgG2, gender, age, waist circumference, smoking status, blood pressure, total and HDL cholesterol, triglycerides, fasting and 2 h post-load plasma glucose.	2 h post-load glucose	−0.240 (−0.050 to −0.018)	<0.0001
	Waist circumference	−0.201 (−0.084 to −0.023)	0.001
	Age	0.146 (0.007 to 0.101)	0.03
	IgG2	−0.130 (−0.563 to −0.038)	0.03
Model 4 IgG2, gender, age, BMI, smoking status, blood pressure, total and HDL cholesterol, triglycerides, fasting and 2 h post-load plasma glucose, hsCRP, white blood cell count, and complement C3.	2 h post-load glucose	−0.217 (−0.047 to −0.015)	<0.0001
	BMI	−0.153 (−0.169 to −0.014)	0.02
	hsCRP	−0.138 (−0.971 to −0.011)	0.04
	IgG2	−0.115 (−0.541 to −0.024)	0.03

Linear regression analysis in models including insulin-stimulated insulin sensitivity as dependent variables and gender, age, BMI, waist circumference, smoking status, systolic and diastolic blood pressure, total and HDL cholesterol, triglycerides, fasting and 2 h post-load plasma glucose, hsCRP, white blood cell count, and complement C3 as independent contributors.
BMI = body mass index; hsCRP = high sensitivity C reactive protein; HDL = high density lipoprotein.

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