Table 1 Differentially expressed COPD disease network module genes in four datasets with adjusted p-values < 0.05.

From: Integration of Molecular Interactome and Targeted Interaction Analysis to Identify a COPD Disease Network Module

Gene.symbol

logFC

adj.P. Val

P. Value

Shaykhiev2009-Alveolar macrophages

Non-smoker vs COPD

IL32

−3.770

0.0014

1.35E-06

ADAM11

−1.441

0.0342

0.0004

CXCL5

−2.049

0.0359

0.0004

MMP7

1.952

0.0381

0.0005

AP3D1

0.451

0.0387

0.0005

MMP12

2.390

0.0423

0.0006

Tedrow2013-Lung

Control vs COPD

MMP1

2.452

0.0069

3.13E-05

TGFB2

−0.768

0.0141

0.0001

WISP1

1.410

0.0158

0.0002

PRSS3

1.023

0.0165

0.0002

MMP9

1.238

0.0240

0.0004

TGFBR3

−0.629

0.0298

0.0006

CAT

−0.466

0.0306

0.0007

SRPX2

0.728

0.0401

0.0011

MMP12

1.621

0.0433

0.0013

Singh2011-Eclipse sputum

GOLD I vs GOLD IV

FAM115A

−1.228

0.0023

2.78E-06

HHIP

−0.645

0.0046

2.91E-05

CAT

−0.535

0.0047

3.17E-05

SERPINE1

0.969

0.0088

0.0002

CAT

−0.683

0.0100

0.0002

CHRNA3

−0.875

0.0109

0.0003

MMP1

1.320

0.0157

0.0006

CXCL1

0.494

0.0167

0.0007

TNFRSF14

0.492

0.0176

0.0008

F12

0.485

0.0184

0.0008

LTBP2

0.722

0.0205

0.0010

BPI

0.870

0.0229

0.0013

CTRC

0.625

0.0273

0.0019

FBN1

−1.399

0.0278

0.0019

COL14A1

−0.410

0.0288

0.0021

SERPINA1

0.592

0.0294

0.0021

FBXL5

0.400

0.0384

0.0035

PLAUR

0.283

0.0394

0.0037

PTCH1

−0.753

0.0394

0.0037

Steiling2013-bronchial brushing

Current smokers NO-COPD-Current smokers with COPD

CDON

−0.264

0.0296

0.0005

LYPD3

0.218

0.0370

0.0009

GSDMB

0.322

0.0431

0.0012

CHRNA7

0.185

0.0438

0.0013

CTGF

0.237

0.0477

0.0016

TNFAIP1

0.126

0.0495

0.0018

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