Figure 2 | Scientific Reports

Figure 2

From: Differential Proteome Analysis of Human Neuroblastoma Xenograft Primary Tumors and Matched Spontaneous Distant Metastases

Figure 2

Primary tumor growth and post-operative metastasis patterns. (A) Primary tumor and post-operative metastasis growth periods of LAN-1 xeno-engrafted into 18 individual mice. Note that 12 of 18 mice developed distant metastasis detectable by BLI within a maximum of 90 days after injection. (B) Frequency of different sites affected by metastasis. (C–E) Examples of in vivo and ex vivo bioluminescent images of liver, kidney, adrenal gland, ovarian and lung metastases and corresponding histology. Please note the size differences of metastases at different sites suggesting particularly rapid metastatic outgrowth in the ovaries (D). Immunohistochemistry for human NCAM demonstrates the human origin of metastatic lesions (E). Met = metastasis; LP = liver parenchyma; AM = adrenal medulla; AC = adrenal cortex; G = glomerulum.

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