Figure 5 | Scientific Reports

Figure 5

From: Transgenic zebrafish model for quantification and visualization of tissue toxicity caused by alloying elements in newly developed biodegradable metal

Figure 5The alternative text for this image may have been generated using AI.

Biological effect of Al3+ in vitro and in a zebrafish model. (a) Viability of HL-1 and Huh7 cells and HUVECs after treatment with indicated ion solutions for 12 h. (b) Biological status of embryos (normal or defective) at 6 hpf after treatment with indicated ion solutions. (c) Biological defects in embryo at 6 hpf after treatment with indicated ion solutions. (d) Representative images of ion-treated zebrafish embryos used to determine heart rate. (e) Mean heart rate of zebrafish embryos following 48-, 72-, and 96-h treatments with different concentrations of Al3+. (f) Representative images of ion-treated zebrafish embryo used to determine liver size at 96 and 168 hpf. (e) Mean liver size of zebrafish embryos following 96-and 168-h treatments with indicated concentrations of Al3+. *, #, &, and +, Significant difference vs. 0, 2.5, and 5 μM of Al3+, respectively.

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