Figure 10 | Scientific Reports

Figure 10

From: Essential Nucleoid Associated Protein mIHF (Rv1388) Controls Virulence and Housekeeping Genes in Mycobacterium tuberculosis

Figure 10

mIHF contacted regions on the H37Rv chromosome. The upper panel shows the global distribution of mIHF in exponentially growing cells (exp, in black) and in mIHF-depleted cells (dep, red). The number of reads is indicated on the y-axis, while gene length and names are shown on the x-axis. Zoomed images show examples of mIHF binding. (a) mIHF peak at rv0097, whose transcription is 10.5-fold downregulated upon mIHF depletion. (b) No peak is located close to the top upregulated genes rv0196 and rv0197. (c) Third top-scoring peak cluster close to mprA/mprB. (d) Accumulation of peaks around mmpL9. (e) EspA extended promoter region.

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