Figure 4
Daily dexamethasone treatment delays collagen promoter activation and NIS signal in Col1α1-hNIS transgenic rats following rotator cuff injury. (a) Transverse PET/CT fusion images overtime following injury showing activation of the Col1α1 promoter and positive NIS signals by uptake of 18F-TFB in the left shoulder of control (saline treated) and daily dexamethasone (2 mg/kg) treated Col1α1-hNIS transgenic rats. (b) Quantification of NIS-mediated 18F-TFB uptake overtime in the left shoulder of Col1α1-hNIS rats following rotator cuff injury with and without dexamethasone treatment. (n = 3–4 for each treatment group). Significance was determined by two sample t-test analysis at each time point, *p < 0.05, ns = not significantly different.
