Figure 7 | Scientific Reports

Figure 7

From: Pharmacological Characterization of Dezocine, a Potent Analgesic Acting as a κ Partial Agonist and μ Partial Agonist

Figure 7

Effects of Dezocine on κ agonist U50,488H-induced antinociception. (A) Dezocine did not affect U50,488H-produced antinociceptive effects. (B) In the presence of μ antagonist β-FNA, pretreatment with Dezocine significantly decreased the antinociceptive effects produced by U50,488 H. Mice were injected with U50,488 H and Dezocine with or without β-FNA. After 15 min, the antinociception was measured in the abdominal constriction test. Data are presented as mean ± SEM from at least 10 mice. *p < 0.05 in comparison with U50,488 H + β-FNA group.

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