Table 3 ED50 values of the antinociception produced by Dezocine and Morphine.

From: Pharmacological Characterization of Dezocine, a Potent Analgesic Acting as a κ Partial Agonist and μ Partial Agonist

Compounds

Antinociception ED50 (mg/kg)

Hot plate test

Abdominal constriction test

Formalin test Phase I Phase II

Dezocine

—

0.2 (0.1–0.2)

0.4 (0.2–1.0)

0.4 (0.2–0.9)

Morphine

6.9 (5.6–8.5)a

0.8 (0.5–1.2)a

5.1 (4.3–5.9)b

3.1 (2.8–3.3)b

  1. The antinociceptive ED50 values were calculated from data obtained at 15 min after drug administration. In parentheses are 95% confidence limits.
  2. a,bThe data of morphine associated with hot-plate test, abdominal constriction test and formalin test were cited from our previous data34,35.
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