Figure 6 | Scientific Reports

Figure 6

From: Predilection of Low Protein C-induced Spontaneous Atherothrombosis for the Right Coronary Sinus in Apolipoprotein E deficient mice

Figure 6

Plaque composition of siNEG and siProc treated Apoe−/− mice. (A,B) Representative photomicrograph of a Masson’s Trichrome stained plaque in the aortic root (RCS) of mice treated with siProc, without (A) and with (B) a thrombus associated to a plaque from the aortic root. Blue areas were assessed as collagen-positive, non-stained areas as necrotic core, and pink nucleated areas as macrophage content/foam cells. The scattered black lines mark borders of the plaque. Black bars represent 200 μm. (C–F) Individual plaques from the siProc treated group are divided in plaques without a thrombus (siProc − THR) and plaques containing a thrombus (siProc + THR). (C) Total plaque area, (D) collagen, (E) cellular content, (F) necrotic core. For all panels, the indicated values represent an average measurement of three sections. Black bars indicate the median. $P < 0.05 for siProc − THR vs. siProc + THR.

Back to article page